Pterocarpanquinones and carbapterocarpans with anti-tumor activity against MDR leukemias

(Bentham Science Publishers) The pterocarpanquinone LQB-118 and the carbapterocarpan LQB-223 were evaluated on models of human hematological neoplasias and solid tumors. Both compounds presented great selectivity and anti-MDR capabilities, seeming to 'adapt' their mode of action to circumvent diverse phenotypes of drug resistance, especially on leukemic cells.